The confirmation of Mpox cases in the Ayos Health District prompted the deployment of a rapid field investigation to better understand the epidemiological situation. The mission sought to identify potential sources of infection, assess the effectiveness of the surveillance system, and reinforce coordination among health, veterinary, environmental, and community stakeholders in line with the One Health approach.

The mission focused on active case finding, evaluation of the disease surveillance system, community investigations, and risk communication activities targeting vulnerable populations. Biological samples were collected from suspected cases, contacts, and rodents. The findings highlighted the persistence of high-risk community practices and underscored the critical importance of early case reporting, community awareness, and sustained preventive measures to limit the spread of Mpox.